MALDI-Based

Shimadzu’s benchtop MALDI-TOF mass spectrometry systems represent a significant advancement in laboratory footprint optimization without compromising analytical rigor. Technically, these instruments utilize Matrix-Assisted Laser Desorption/Ionization (MALDI) coupled with a Time-of-Flight (TOF) analyzer to provide rapid and accurate molecular weight determination for a wide array of analytes.

Shimadzu’s floor-standing MALDI-TOF mass spectrometry systems are engineered for researchers requiring the highest levels of performance in mass resolution, accuracy, and structural elucidation. Technically, these instruments utilize an extended flight tube architecture and advanced ion optics to achieve superior separation of ions based on their mass-to-charge ratio. Designed for demanding applications in proteomics, glycan analysis, and polymer science.

Shimadzu’s MALDI imaging solutions integrate high-end mass spectrometry with advanced optical microscopy to visualize the spatial distribution of biomolecules directly from tissue sections. Technically, these systems allow for the label-free mapping of metabolites, lipids, drugs, and proteins by correlating mass spectral intensities with precise X-Y coordinates on a sample. The core of this technology lies in the fusion of atmospheric pressure MALDI (AP-MALDI) sources.

Shimadzu’s Microbial Identification Solutions leverage the speed and sensitivity of Matrix-Assisted Laser Desorption/Ionization Time-of-Flight (MALDI-TOF) mass spectrometry to revolutionize taxonomic classification. Technically, these systems identify microorganisms by analyzing the unique protein "fingerprints" of intact cells or lysates, primarily focusing on highly conserved ribosomal proteins.

Shimadzu’s MALDI software ecosystem is technically anchored by the MALDI Solutions™ suite, a centralized platform designed to unify instrument control, data acquisition, and post-run analysis. This software architecture utilizes a secure, multi-user Microsoft SQL database to manage sample worklists, acquisition parameters, and spectral data, ensuring high data integrity and facilitating compliance with 21 CFR Part 11 regulations. 

Shimadzu’s MALDI consumables are technically developed to ensure the highest degree of reproducibility and sensitivity in mass spectrometry workflows. These specialized materials are essential for the effective ionization of a wide range of analytes, from small molecules to large biomolecular complexes. The range includes high-purity chemical matrices, calibration standards, and various sample target formats designed to minimize chemical noise and maximize signal-to-noise ratios.