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Mettler Toledo Multichannel Electronic Pipettes

For consistent high-throughput work, nothing compares with the E4 XLS+ electronic multichannel pipette. Fast loading, ergonomic handling and absolute precision across all channels are Rainin hallmarks.

Built to perform

The cushioned joystick selector makes it easy to configure and run protocols. When dispensing multiple aliquots across multiple channels, you'll get consistent volume and identical speed at every step. Automate cycle counting so you can concentrate on other details, and relieve your thumb with options to auto-mix or auto-dispense. It's easy to store settings so you can duplicate an assay later.

Ergonomic pipette

Designed for use with either hand, the E4 XLS+ electronic multichannel pipette fits like a glove is extraordinarily well balanced while pipetting. The carefully shaped finger hook enables you to relax your grip. Extremely light operating forces and a silicone shock absorber built into the tip ejector make the E4 a pleasure to work with. On LTS-equipped models, tip ejection force is just 0.6 kg.

Compliant pipette

To accommodate GLP/GMP compliance, the E4 makes it possible to password-protect pipette settings, protocols and service alarms. Service records, cycles and status data are completely tamper-proof.

Accurate and Precise

All piston movements are controlled by the onboard microprocessor, which moves the piston the set distance at the set speed, regardless of user. The advanced stepper motor has 4,000 discrete steps, providing highly precise liquid measurements. At the end of each pipetting cycle the E4 XLS+ re-calibrates itself by resetting the zero point.

Faster Throughput

Speed up your plate work with Rainin’s E4 XLS+ electronic multichannel pipettes. Special modes streamline how you transfer multiple aliquots, perform serial dilutions and program complex pipetting routines.

Absolutely consistent sample pickup

Patented LTS tip and nozzle design provides exceptionally easy multichannel tip mounting. Perfect sealing – first time, every time – without rocking or hand-tightening.

Simplify Repetitive Pipetting

Multi-dispense takes the drudgery out of repetitive pipetting by calculating how many aliquots can be dispensed from a single pickup. Autopace simplifies repeat dispensing – click the joystick once and repeat dispense across a plate.


No manual required! The E4’s large color screen, carousel navigation and joystick control make operation easy and highly intuitive. From straightforward pipetting to complex applications, this tool can do it all. Its long-life battery gives a day’s worth of pipetting with minimal charging and will last for thousands of recharges.

GLP/GMP Secure

Reduce compliance risks! Onboard service data is extremely secure and quick to access. Avoid calibration compliance errors by password protecting access to service interval alarms. Minimize pipetting SOP deviations by locking protocol settings.

Highly Configurable

The E4s’ Admin Mode enables you configure the pipette any way you want. For convenience or security, remove unwanted modes or lock in settings. Create personalized setting profiles to “re-set” your pipette to a preferred configuration.

Save your Protocols!

Store multiple custom protocols in the on-board memory. Simultaneously review and select your protocols with a simple movement of the joystick. No more re-entering preferred protocols over and over again!

PureSpeed on Board

Purify biomolecules from proteins to oligonucleotides to chromatin using E4 XLS+ electronic multichannel pipette adjustable spacer pipettes and Rainin’s PureSpeed™ tips. Unite rapid and gentle processing of multiple samples with high elution concentration for an unbeatable combination! All E4 have the PureSpeed functionality pre-installed.


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